Protein Details: Glutamate receptor ionotropic; kainate 4

Protein ID

ICDB_Pro_0741

Protein Name

Glutamate receptor ionotropic; kainate 4

Gene Name

Grik4

Organism

Rattus norvegicus (Rat)

Length

956 amino acids

AlphaFoldDB

AF-Q01812-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and shows channel activity only in heteromeric assembly with GRIK1; GRIK2 and GRIK3 subunits.

Sequence

MPRVSAPLVLLPAWLLMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSSLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMMTELRSIILCQDNIHPRRRRSGGLPPQPPVLEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWDKTTNSSEPE

PDB Structures

5IKB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 500; /ligand="L-glutamate"; BINDING 502; /ligand="L-glutamate"; BINDING 507; /ligand="L-glutamate"; BINDING 674; /ligand="L-glutamate"; /ligand="L-glutamate"; BINDING 723; /ligand="L-glutamate"

Disease

Location

Strong expression in hippocampal CA3 pyramidal cells. Low expression in hippocampal dentate granule cells; in layers II; V and VI of the cortex; and in cerebellar Purkinje cells. No expression in the striatum; reticular thalamus; hypothalamus or amygdaloid complex. No expression in the striatum; reticular thalamus; hypothalamus or amygdaloid complex. No expression in the striatum; reticular thalamus; hypothalamus or amygdaloid complex.

DOI ID

10.1038/351742a0; 10.1016/s0896-6273(00)80404-3; 10.1016/j.neuroscience.2014.08.009; 10.1016/j.str.2016.06.019

RefSeq

NP_036704.1; XP_017450943.1; XP_017450944.1